Significant functional heterogeneity among KIR2DL1 alleles and a pivotal role of arginine245
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چکیده
منابع مشابه
Significant functional heterogeneity among KIR2DL1 alleles and a pivotal role of arginine 245.
Killer immunoglobulin-like receptors (KIRs) play an essential role in the regulation of natural killer cell functions. KIR genes are highly polymorphic in nature, showing both haplotypic and allelic variations among people. We demonstrated in both in vitro and in vivo models a significant heterogeneity in function among different KIR2DL1 alleles, including their ability to inhibit YT-Indy cells...
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ژورنال
عنوان ژورنال: Blood
سال: 2009
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2009-07-231977